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l-norepinephrine Pharmacology and 2-Methyl-3-(trifluoromethyl)aniline

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l-norepinephrine Pharmacology and 2-Methyl-3-(trifluoromethyl)aniline Empty l-norepinephrine Pharmacology and 2-Methyl-3-(trifluoromethyl)aniline

Post  angel110 Fri Jul 01, 2011 11:48 pm

2-Methyl-3-(trifluoromethyl)aniline’s Synonym is 3-Amino-2-methylbenzotrifluoride; 3-Trifluoromethyl-o-toluidine, CAS Number is 54396-44-0, Molecular Formula is C8H8F3, Molecular Weight is 175.15, Beilstein Registry Number is 2832865, EC Number is 259-145-5, MDL number is MFCD00153216, Purity is 98%, MP is 38-42 °C(lit.).

2-Methyl-3-(trifluoromethyl)aniline should be kept container tightly closed in a dry and well-ventilated place. It’s appearance is solid.

Pharmacology:Epinephrine is indicated for intravenous injection in treatment of acute hypersensitivity, treatment of acute asthmatic attacks to relieve bronchospasm, and treatment and prophylaxis of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome). The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation. When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors.



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