Pharmacodynamics of Acetylcysteine
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Pharmacodynamics of Acetylcysteine
Acetylcysteine (or N-acetylcysteine or N-acetyl-L-cysteine), with its CAS registry number 616-91-1, has its IUPAC name of (2R)-2-acetamido-3-sulfanylpropanoic acid. This chemical belongs to the classes of Amino Acids, and it is applied as a pharmaceutical drug and nutritional supplement which is used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose.
Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining or restoring the Glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.
Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining or restoring the Glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.
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