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the basic information of Pyroglutamic acid

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the basic information of  Pyroglutamic acid Empty the basic information of Pyroglutamic acid

Post  bluesky Wed Apr 21, 2010 12:59 am

Pyroglutamic acid (also known as pidolic acid, or pyroglutamate for its basic form) is an uncommon amino acid derivative in which the free amino group of glutamic acid cyclizes to form a lactam. It is found in many proteins including bacteriorhodopsin. N-terminal glutamine residues can spontaneously cyclize to become pyroglutamate. Just D-PYROGLUTAMIC-ACID, it is one of Pyroglutamate derivatives.

Pyroglutamate has been shown to be effective in alcohol-induced memory deficits in humans and, more recently, in people affected with multi-infarct dementia (Scoppa, in press). In these patients, the administration of pyroglutamate brought about a significant increase of attention and an improvement on psychological tests investigating short-term retrieval, long-term retrieval, and long-term storage of memory. A statistically significant improvement was observed also in the consolidation of memory. In Italy, arginine pyroglutamate (one source of pyroglutamate) is used to treat senility, mental retardation, and alcoholism.And In Italy, arginine pyroglutamate (one source of pyroglutamate) is used to treat senility, mental retardation, and alcoholism .
All in all, evidence suggests that pyroglutamic acid plays an important role in the preservation of the important brain transmitter acetylcholine and oxygenation in the brain. The presence and prolonged existence of this neurotransmitter ACh in the brain shows enhancement in patient memory.

bluesky

Posts : 41
Join date : 2010-04-05

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