Synthesis and decomposition of cyclic AMP

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 Synthesis and decomposition of cyclic AMP Empty Synthesis and decomposition of cyclic AMP

Post  gill on Mon Nov 08, 2010 1:29 am

cyclic AMP is a second messenger important in many biological processes. cyclic AMP is derived from adenosine triphosphate (ATP) and used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. cyclic AMP is synthesised from ATP by adenylyl cyclase located on the inner side of the plasma membrane. Adenylyl cyclase is activated by a range of signaling molecules through the activation of adenylyl cyclase stimulatory G (Gs)-protein-coupled receptors and inhibited by agonists of adenylyl cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylyl cyclase responds more strongly to glucagon, and muscle adenylyl cyclase responds more strongly to adrenaline. cyclic AMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.


gill

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